Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer.

ABSTRACT:

Background

Bladder cancer (BCa) is the ninth most common form of cancer in the world. There is a continuing need not only for improving the accuracy of diagnostic markers but also for the development of new treatment strategies. Recent studies have shown that the renin-angiotensin system (RAS), which include the angiotensin type 1 (AT1R), type 2(AT2R), and Mas receptors, play an important role in tumorigenesis and may guide us in meeting those needs.

Results

In this study, we first observed that AT1R and Mas expression levels were significantly upregulated in BCa specimens while AT2R was significantly downregulated. Viral vector mediated overexpression of AT2R induced apoptosis and dramatically suppressed BCa cell proliferation in vitro, suggesting a therapeutic effect. Inve

SUBMITTER: Pei N 

PROVIDER: S-EPMC5466725 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature