Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia.

ABSTRACT:

Background

The proton magnetic resonance spectroscopy (¹H-MRS) signals from glutamate (or the combined glutamate and glutamine signal-Glx) have been found to be greater in various brain regions in people with schizophrenia. Recently, the Psychiatric Genetics Consortium reported that several common single-nucleotide polymorphisms (SNPs) in glutamate-related genes confer increased risk of schizophrenia. Here, we examined the relationship between presence of these risk polymorphisms and brain Glx levels in schizophrenia.

Methods

¹H-MRS imaging data from an axial, supraventricular tissue slab were acquired in 56 schizophrenia patients and 67 healthy subjects. Glx was measured in gray matter (GM) and white matter (WM) regions. The genetic data included six p

SUBMITTER: Bustillo JR 

PROVIDER: S-EPMC5466972 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature