Importance of Campylobacter jejuni FliS and FliW in Flagella Biogenesis and Flagellin Secretion.

ABSTRACT: Flagella-driven motility enables bacteria to reach their favorable niche within the host. The human foodborne pathogen Campylobacter jejuni produces two heavily glycosylated structural flagellins (FlaA and FlaB) that form the flagellar filament. It also encodes the non-structural FlaC flagellin which is secreted through the flagellum and has been implicated in host cell invasion. The mechanisms that regulate C. jejuni flagellin biogenesis and guide the proteins to the export apparatus are different from those in most other enteropathogens and are not fully understood. This work demonstrates the importance of the putative flagellar protein FliS in C. jejuni flagella assembly. A constructed fliS knockout strain was non-motile, displayed reduced levels of FlaA/B an

SUBMITTER: Radomska KA 

PROVIDER: S-EPMC5466977 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature