Distinct Transcriptional and Alternative Splicing Signatures of Decidual CD4⁺ T Cells in Early Human Pregnancy.

ABSTRACT: Decidual CD4⁺ T (dCD4 T) cells are crucial for the maternal-fetal immune tolerance required for a healthy pregnancy outcome. However, their molecular and functional characteristics are not well elucidated. In this study, we performed the first analysis of transcriptional and alternative splicing (AS) landscapes for paired decidual and peripheral blood CD4⁺ T (pCD4 T) cells in human early pregnancy using high throughput mRNA sequencing. Our data showed that dCD4 T cells are endowed with a unique transcriptional signature when compared to pCD4 T cells: dCD4 T cells upregulate 1,695 genes enriched in immune system process whereas downregulate 1,011 genes mainly related to mRNA catabolic process and the ribosome. Moreover, dCD4 T cells were observed to be at M phase, and

SUBMITTER: Zeng W 

PROVIDER: S-EPMC5466981 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature