Ontology highlight
ABSTRACT:
SUBMITTER: Griffin BD
PROVIDER: S-EPMC5467228 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Nature communications 20170607
Zika virus (ZIKV) is an emerging pathogen causally associated with serious sequelae in fetuses, inducing fetal microcephaly and other neurodevelopment defects. ZIKV is primarily transmitted by mosquitoes, but can persist in human semen and sperm, and sexual transmission has been documented. Moreover, exposure of type-I interferon knockout mice to ZIKV results in severe damage to the testes, epididymis and sperm. Candidate ZIKV vaccines have shown protective efficacy in preclinical studies carrie ...[more]