Survival of Del17p CLL Depends on Genomic Complexity and Somatic Mutation.

ABSTRACT:

Purpose

Chronic lymphocytic leukemia (CLL) with 17p deletion typically progresses quickly and is refractory to most conventional therapies. However, some del(17p) patients do not progress for years, suggesting that del(17p) is not the only driving event in CLL progression. We hypothesize that other concomitant genetic abnormalities underlie the clinical heterogeneity of del(17p) CLL.

Experimental design

We profiled the somatic mutations and copy number alterations (CNA) in a large group of del(17p) CLLs as well as wild-type CLL and analyzed the genetic basis of their clinical heterogeneity.

Results

We found that increased somatic mutation number associates with poor overall survival independent of 17p deletion (P = 0.003). TP53 mutation was present in 81% of del(17p)

SUBMITTER: Yu L 

PROVIDER: S-EPMC5467311 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature