Association between hepatitis B co-infection and elevated liver stiffness among HIV-infected adults in Lusaka, Zambia.

ABSTRACT:

Objective

To describe liver disease epidemiology among HIV-infected individuals in Zambia.

Methods

We recruited HIV-infected adults (≥18 years) at antiretroviral therapy initiation at two facilities in Lusaka. Using vibration controlled transient elastography, we assessed liver stiffness, a surrogate for fibrosis/cirrhosis, and analysed liver stiffness measurements (LSM) according to established thresholds (>7.0 kPa for significant fibrosis and >11.0 kPa for cirrhosis). All participants underwent standardised screening for potential causes of liver disease including chronic hepatitis B (HBV) and C virus co-infection, herbal medicine, and alcohol use. We used multivariable logistic regression to identify factors associated with elevated liver stiffness.

Results

Among 7

SUBMITTER: Vinikoor MJ 

PROVIDER: S-EPMC5467871 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature