A genome-scale metabolic reconstruction of Lysinibacillus sphaericus unveils unexploited biotechnological potentials.

ABSTRACT: The toxic lineage (TL) of Lysinibacillus sphaericus has been extensively studied because of its potential biotechnological applications in biocontrol of mosquitoes and bioremediation of toxic metals. We previously proposed that L. sphaericus TL should be considered as a novel species based on a comparative genomic analysis. In the current work, we constructed the first manually curated metabolic reconstruction for this species on the basis of the available genomes. We elucidated the central metabolism of the proposed species and, beyond confirming the reported experimental evidence with genomic a support, we found insights to propose novel applications and traits to be considered in further studies. The strains belonging to this lineage exhibit a broad repertory of genes encoding insectici

SUBMITTER: Gomez-Garzon C 

PROVIDER: S-EPMC5467902 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature