HLA-A*24:02 as a common risk factor for antiepileptic drug-induced cutaneous adverse reactions.

ABSTRACT:

Objective

To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions.

Methods

A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers. Important genotypes were replicated in cases with maculopapular eruption and in the meta-analyses of data from other populations. Sequence-based typing determined the HLA-A, HLA-B, HLA-C, and HLA-DRB1 genotypes.

Results

HLA-B*15:02 was confirmed as strongly associ

SUBMITTER: Shi YW 

PROVIDER: S-EPMC5467955 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature