Reconstructing blood stem cell regulatory network models from single-cell molecular profiles.

ABSTRACT: Adult blood contains a mixture of mature cell types, each with specialized functions. Single hematopoietic stem cells (HSCs) have been functionally shown to generate all mature cell types for the lifetime of the organism. Differentiation of HSCs toward alternative lineages must be balanced at the population level by the fate decisions made by individual cells. Transcription factors play a key role in regulating these decisions and operate within organized regulatory programs that can be modeled as transcriptional regulatory networks. As dysregulation of single HSC fate decisions is linked to fatal malignancies such as leukemia, it is important to understand how these decisions are controlled on a cell-by-cell basis. Here we developed and applied a network inference method, exploiting the a

SUBMITTER: Hamey FK 

PROVIDER: S-EPMC5468644 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature