Genome-wide use of high- and low-affinity Tbrain transcription factor binding sites during echinoderm development.

ABSTRACT: Sea stars and sea urchins are model systems for interrogating the types of deep evolutionary changes that have restructured developmental gene regulatory networks (GRNs). Although cis-regulatory DNA evolution is likely the predominant mechanism of change, it was recently shown that Tbrain, a Tbox transcription factor protein, has evolved a changed preference for a low-affinity, secondary binding motif. The primary, high-affinity motif is conserved. To date, however, no genome-wide comparisons have been performed to provide an unbiased assessment of the evolution of GRNs between these taxa, and no study has attempted to determine the interplay between transcription factor binding motif evolution and GRN topology. The study here measures genome-wide binding of Tbrain orthologs by usin

SUBMITTER: Cary GA 

PROVIDER: S-EPMC5468674 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature