Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.

ABSTRACT: Inflammation and microbiota are critical components of intestinal tumorigenesis. To dissect how the microbiota contributes to tumor distribution, we generated germ-free (GF) Apc^Min/+ and Apc^Min/+ ;Il10^-/- mice and exposed them to specific-pathogen-free (SPF) or colorectal cancer-associated bacteria. We found that colon tumorigenesis significantly correlated with inflammation in SPF-housed Apc^Min/+ ;Il10^-/- , but not in Apc^Min/+ mice. In contrast, small intestinal neoplasia development significantly correlated with age in both Apc^Min/+ ;Il10^-/- and Apc^Min/+ mice. GF Apc^Min/+ ;Il10^-/- mice convent

SUBMITTER: Tomkovich S 

PROVIDER: S-EPMC5468752 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature