Severe hypertriglyceridemia in Norway: prevalence, clinical and genetic characteristics.

ABSTRACT:

Background

There is a lack of comprehensive patient-datasets regarding prevalence of severe hypertriglyceridemia (sHTG; triglycerides ≥10 mmol/L), frequency of co-morbidities, gene mutations, and gene characterization in sHTG. Using large surveys combined with detailed analysis of sub-cohorts of sHTG patients, we here sought to address these issues.

Methods

We used data from several large Norwegian surveys that included 681,990 subjects, to estimate the prevalence. Sixty-five sHTG patients were investigated to obtain clinical profiles and candidate disease genes. We obtained peripheral blood mononuclear cells (PBMC) from six male patients and nine healthy controls and examined expression of mRNAs involved in lipid metabolism.

Results

The prevalence of sHTG was 0.13 (9

SUBMITTER: Retterstol K 

PROVIDER: S-EPMC5469061 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature