Serological signatures of declining exposure following intensification of integrated malaria control in two rural Senegalese communities.

ABSTRACT: Recent control scale-up has reduced malaria in many areas but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. Although serology is considered a promising approach in this regard, the serological impact of control interventions has been so far studied using indirect quantification of exposure. Cohort surveys concomitantly recording entomological and malariometric indices have been conducted in two Senegalese settings where supervised control intensification implemented in 2006 shifted malaria from historically holoendemic in Dielmo and mesoendemic in Ndiop to hypoendemic in both settings by 2013. We analyse here serological signatures of declining transmission using archived blood samples. Responses against ten pre-erythro

SUBMITTER: Perraut R 

PROVIDER: S-EPMC5469466 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature