Quickly identifying identical and closely related subjects in large databases using genotype data.

ABSTRACT: Genome-wide association studies (GWAS) usually rely on the assumption that different samples are not from closely related individuals. Detection of duplicates and close relatives becomes more difficult both statistically and computationally when one wants to combine datasets that may have been genotyped on different platforms. The dbGaP repository at the National Center of Biotechnology Information (NCBI) contains datasets from hundreds of studies with over one million samples. There are many duplicates and closely related individuals both within and across studies from different submitters. Relationships between studies cannot always be identified by the submitters of individual datasets. To aid in curation of dbGaP, we developed a rapid statistical method called Genetic Relationship and

SUBMITTER: Jin Y 

PROVIDER: S-EPMC5469481 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature