Patient-reported Symptoms of Tenosynovial Giant Cell Tumors.

ABSTRACT:

Purpose

Tenosynovial giant cell tumor (TGCT), a rare locally aggressive neoplasm of the synovium of joints and tendon sheaths, is associated with joint destruction, inflammation, pain, and swelling, in part due to colony-stimulating factor 1 receptor-bearing macrophages recruited to the tumor by genetic elevation of colony-stimulating factor 1 activity. The most common treatment is surgery, although promising pharmacologic treatments are in development. Patient-reported outcome (PRO) instruments are critical end points in demonstrating the clinical relevance of standard oncologic outcome measures and the overall impact of novel pharmacologic therapies in nonmalignant neoplastic conditions such as TGCT. The content validity of PROs relevant to patients with TGCT has not been formall

SUBMITTER: Gelhorn HL 

PROVIDER: S-EPMC5469507 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature