ZnO Film Bulk Acoustic Resonator for the Kinetics Study of Human Blood Coagulation.

ABSTRACT: Miniaturized and rapid blood coagulation assay technologies are critical in many clinical settings. In this paper, we present a ZnO film bulk acoustic resonator for the kinetic analysis of human blood coagulation. The resonator operated in thickness shear resonance mode at 1.4 GHz. When the resonator contacted the liquid environment, the viscous loading effect was considered as the additional resistance and inductance in the equivalent circuits, resulting in a linear relationship with a slope of approximately -217 kHz/cP between the liquid viscosity and the frequency of the resonator. The downshift of the resonant frequency and the viscosity change during the blood coagulation were correlated to monitor the coagulation process. The sigmoidal trend was observed in the frequency response for

SUBMITTER: Chen D 

PROVIDER: S-EPMC5469538 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature