Antithrombotic agents for secondary prevention after acute coronary syndromes: A systematic review and network meta-analysis.

ABSTRACT:

Background

Nine oral antithrombotic medications currently available in the United States and Europe have been studied in clinical trials for secondary prevention of cardiac events following acute coronary syndrome (ACS). Few combinations of these medications have been directly compared, and studies have used multiple different comparator regimens.

Methods

We performed a systematic review and network meta-analysis of randomized controlled trials evaluating one or more available oral antithrombotic therapies in patients with ACS or prior myocardial infarction (MI). Co-primary outcomes were all-cause and cardiovascular mortality compared with imputed placebo and aspirin monotherapy.

Results

Forty-seven studies (196,057 subjects) met inclusion criteria and were included i

SUBMITTER: Fanaroff AC 

PROVIDER: S-EPMC5469706 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature