Insights into enterotoxigenic Escherichia coli diversity in Bangladesh utilizing genomic epidemiology.

ABSTRACT: Enterotoxigenic Escherichia coli (ETEC) cause more than 500,000 deaths each year in the developing world and are characterized on a molecular level by the presence of genes that encode the heat-stable (ST) and/or heat-labile (LT) enterotoxins, as well as surface structures, known as colonization factors (CFs). Genome sequencing and comparative genomic analyses of 94 previously uncharacterized ETEC isolates demonstrated remarkable genomic diversity, with 28 distinct sequence types identified in three phylogenomic groups. Interestingly, there is a correlation between the genomic sequence type and virulence factor profiles based on prevalence of the isolate, suggesting that there is an optimal combination of genetic factors required for survival, virulence and transmission in the most success

SUBMITTER: Sahl JW 

PROVIDER: S-EPMC5469772 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature