Isothiocyanates are detected in human synovial fluid following broccoli consumption and can affect the tissues of the knee joint.

ABSTRACT: Osteoarthritis is a major cause of disability and there is no current pharmaceutical treatment which can prevent the disease or slow its progression. Dietary advice or supplementation is clearly an attractive option since it has low toxicity and ease of implementation on a population level. We have previously demonstrated that sulforaphane, a dietary isothiocyanate derived from its glucosinolate precursor which is found in broccoli, can prevent cartilage destruction in cells, in in vitro and in vivo models of osteoarthritis. As the next phase of this research, we enrolled 40 patients with knee osteoarthritis undergoing total knee replacement into a proof-of-principle trial. Patients were randomised to either a low or high glucosinolate diet for 14 days prior to surgery. We detected ITCs in

SUBMITTER: Davidson R 

PROVIDER: S-EPMC5469854 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature