Pentazocine Protects SN4741 Cells Against MPP⁺-Induced Cell Damage via Up-Regulation of the Canonical Wnt/β-Catenin Signaling Pathway.

ABSTRACT: The Wnt/β-catenin signaling pathway has been linked to many neurodegenerative diseases including Parkinson's disease (PD). A glycoprotein named Dickkopf-1 (Dkk1) can combine with the receptor complex on cell membrane to inhibit Wnt/β-catenin signaling. Opioids, a series of compounds including morphine, fentanyl and pentazocine, have been reported to contribute to the up-regulation of Wnt/β-catenin signaling. Naloxone is an antagonist that has been used as an antidote to opioids through mu-opioid receptor. 1-methyl-4-phenylpyridinium (MPP⁺), which serves as a selective toxin for dopaminergic neurons, has been used to create experimental models of PD. In our study, we examined the protective effects of pentazocine against MPP⁺-induced cell death in the nigral dopaminerg

SUBMITTER: Wang J 

PROVIDER: S-EPMC5469889 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature