Role of mass drug administration in elimination of Plasmodium falciparum malaria: a consensus modelling study.

ABSTRACT:

Background

Mass drug administration for elimination of Plasmodium falciparum malaria is recommended by WHO in some settings. We used consensus modelling to understand how to optimise the effects of mass drug administration in areas with low malaria transmission.

Methods

We collaborated with researchers doing field trials to establish a standard intervention scenario and standard transmission setting, and we input these parameters into four previously published models. We then varied the number of rounds of mass drug administration, coverage, duration, timing, importation of infection, and pre-administration transmission levels. The outcome of interest was the percentage reduction in annual mean prevalence of P falciparum parasite rate as measured by PCR in the third year aft

SUBMITTER: Brady OJ 

PROVIDER: S-EPMC5469936 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature