Brain Activation by H₁ Antihistamines Challenges Conventional View of Their Mechanism of Action in Motion Sickness: A Behavioral, c-Fos and Physiological Study in Suncus murinus (House Musk Shrew).

ABSTRACT: Motion sickness occurs under a variety of circumstances and is common in the general population. It is usually associated with changes in gastric motility, and hypothermia, which are argued to be surrogate markers for nausea; there are also reports that respiratory function is affected. As laboratory rodents are incapable of vomiting, Suncus murinus was used to model motion sickness and to investigate changes in gastric myoelectric activity (GMA) and temperature homeostasis using radiotelemetry, whilst also simultaneously investigating changes in respiratory function using whole body plethysmography. The anti-emetic potential of the highly selective histamine H₁ receptor antagonists, mepyramine (brain penetrant), and cetirizine (non-brain penetrant), along with the muscar

SUBMITTER: Tu L 

PROVIDER: S-EPMC5470052 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature