A type IV pilin, PilA, Contributes To Adherence of Burkholderia pseudomallei and virulence in vivo.

ABSTRACT: The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.

SUBMITTER: Essex-Lopresti AE 

PROVIDER: S-EPMC547011 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature