Physical activity, black carbon exposure, and DNA methylation in the FOXP3 promoter.

ABSTRACT:

Background

Physical activity is associated with improvement in lung function; however, pollution exposure during physical activity can lead to a transient reduction in lung function. This paradoxical relationship may be linked to altered T regulatory (Treg) cell activity, which increases with exercise and suppresses airway inflammation, but decreases in association with exposure to air pollution. To clarify these relationships, we investigated buccal cell DNA methylation of the forkhead box p3 (FOXP3) gene promoter, a proposed biomarker of Treg activity. We hypothesized that active urban children would have lower FOXP3 promoter methylation, associated with better lung function compared to non-active children. We also hypothesized that this relationship would be attenu

SUBMITTER: Lovinsky-Desir S 

PROVIDER: S-EPMC5470266 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature