Association of Patent Ductus Arteriosus Ligation With Death or Neurodevelopmental Impairment Among Extremely Preterm Infants.

ABSTRACT:

Importance

Observational studies have associated patent ductus arteriosus (PDA) ligation among preterm infants with adverse neonatal outcomes and neurodevelopmental impairment in early childhood, with a resultant secular trend away from surgical treatment. However, to our knowledge, studies have inadequately addressed sources of residual bias, including survival bias and major neonatal morbidities arising before exposure to ligation.

Objective

Evaluate the association between PDA ligation vs medical management and neonatal and neurodevelopmental outcomes.

Design, setting, and participants

This retrospective cohort study of preterm infants younger than 28 weeks gestational age born between January 1, 2006, and December 31, 2012, with clinical and echocardiography diagn

SUBMITTER: Weisz DE 

PROVIDER: S-EPMC5470355 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature