Human Leukocyte Antigen Class I Genes Associated With Stevens-Johnson Syndrome and Severe Ocular Complications Following Use of Cold Medicine in a Brazilian Population.

ABSTRACT:

Importance

Describing the association with human leukocyte antigen (HLA) alleles could facilitate the understanding of increased risk factors for development of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in patients with severe ocular complications (SOCs).

Objective

To investigate the association between HLA class I genes and cold medicine (CM)-associated SJS/TEN with SOCs.

Design, setting, and participants

This case-control study was conducted between February 8, 2013, and August 29, 2014. Thirty-nine Brazilian patients with CM-SJS/TEN of 74 patients with SJS/TEN with SOCs and 133 healthy Brazilian volunteers were enrolled. Human leukocyte antigen class I genes (HLA-A, HLA-B, and HLA-C) were examined to determine whether there was a genetic p

SUBMITTER: Wakamatsu TH 

PROVIDER: S-EPMC5470496 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature