Chorioamnionitis in the Development of Cerebral Palsy: A Meta-analysis and Systematic Review.

ABSTRACT: Chorioamnionitis (CA) has often been linked etiologically to cerebral palsy (CP). To differentiate association from risk of CA in the development of CP. PubMed, Cochrane Library, Embase, and bibliographies of original studies were searched by using the keywords (chorioamnionitis) AND ((cerebral palsy) OR brain). Included studies had to have: (1) controls, (2) criteria for diagnoses, and (3) neurologic follow-up. Studies were categorized based on: (1) finding incidence of CP in a CA population, or risk of CP; and (2) incidence of CA in CP or association with CP. Two reviewers independently verified study inclusion and extracted data. Seventeen studies (125 256 CA patients and 5 994 722 controls) reported CP in CA. There was significantly increased CP inpreterm histologic chorioamnionitis (H

SUBMITTER: Shi Z 

PROVIDER: S-EPMC5470507 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature