Cognitive states influence dopamine-driven aberrant learning in Parkinson's disease.

ABSTRACT: Individual differences in dopaminergic tone underlie tendencies to learn from reward versus punishment. These effects are well documented in Parkinson's patients, who vacillate between low and high tonic dopaminergic states as a function of medication. Yet very few studies have investigated the influence of higher-level cognitive states known to affect downstream dopaminergic learning in Parkinson's patients. A dopamine-dependent cognitive influence over learning would provide a candidate mechanism for declining cognitive integrity and motivation in Parkinson's patients. In this report we tested the influence of two high-level cognitive states (cost of conflict and value of volition) that have recently been shown to cause predictable learning biases in healthy young adults as a function of

SUBMITTER: Cavanagh JF 

PROVIDER: S-EPMC5470538 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature