In Vivo Murine-Matured Human CD3⁺ Cells as a Preclinical Model for T Cell-Based Immunotherapies.

ABSTRACT: Adoptive cellular immunotherapy is a promising and powerful method for the treatment of a broad range of malignant and infectious diseases. Although the concept of cellular immunotherapy was originally proposed in the 1990s, it has not seen successful clinical application until recent years. Despite significant progress in creating engineered receptors against both malignant and viral epitopes, no efficient preclinical animal models exist for rapidly testing and directly comparing these engineered receptors. The use of matured human T cells in mice usually leads to graft-versus-host disease (GvHD), which severely limits the effectiveness of such studies. Alternatively, adult apheresis CD34⁺ cells engraft in neonatal non-obese diabetic (NOD)-severe combined immunodeficiency (SCID

SUBMITTER: Haworth KG 

PROVIDER: S-EPMC5470556 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature