Murine macrophage transcriptional responses to Bacillus anthracis infection and intoxication.

ABSTRACT: Interactions between Bacillus anthracis and host macrophages represent critical early events in anthrax pathogenesis, but their details are not clearly understood. Here we report the first genomewide characterization of the transcriptional changes within macrophages infected with B. anthracis and the identification of several hundred host genes that were differentially expressed during this intracellular stage of infection. These loci included both genes that are known to be regulated differentially in response to many other bacterial pathogens and those that appear to be differentially regulated in response to B. anthracis but not other bacterial species that have been tested. These data provide a transcriptional basis for a variety of physiological changes observed during infection, incl

SUBMITTER: Bergman NH 

PROVIDER: S-EPMC547061 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature