Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole.

ABSTRACT:

Background

The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC.

Methods and results

Contrast T1-weighted magnetic resonance imaging with gadolinium was performed before and after antiparasitic treatment. Eight NCC-infected pigs were treated with praziquantel plus albendazole and euthanized two (n = 4)

SUBMITTER: Cangalaya C 

PROVIDER: S-EPMC5470720 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature