ROTS: An R package for reproducibility-optimized statistical testing.

ABSTRACT: Differential expression analysis is one of the most common types of analyses performed on various biological data (e.g. RNA-seq or mass spectrometry proteomics). It is the process that detects features, such as genes or proteins, showing statistically significant differences between the sample groups under comparison. A major challenge in the analysis is the choice of an appropriate test statistic, as different statistics have been shown to perform well in different datasets. To this end, the reproducibility-optimized test statistic (ROTS) adjusts a modified t-statistic according to the inherent properties of the data and provides a ranking of the features based on their statistical evidence for differential expression between two groups. ROTS has already been successfully applied in a ran

SUBMITTER: Suomi T 

PROVIDER: S-EPMC5470739 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature