Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease.

ABSTRACT:

Rationale

Severe asthma (SA) is a heterogeneous disease with multiple molecular mechanisms. Gene expression studies of bronchial epithelial cells in individuals with asthma have provided biological insight and underscored possible mechanistic differences between individuals.

Objectives

Identify networks of genes reflective of underlying biological processes that define SA.

Methods

Airway epithelial cell gene expression from 155 subjects with asthma and healthy control subjects in the Severe Asthma Research Program was analyzed by weighted gene coexpression network analysis to identify gene networks and profiles associated with SA and its specific characteristics (i.e., pulmonary function tests, quality of life scores, urgent healthcare use, and steroid use), which pot

SUBMITTER: Modena BD 

PROVIDER: S-EPMC5470748 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature