Genetic and Histopathologic Intertumor Heterogeneity in Primary Aldosteronism.

ABSTRACT:

Context

Whether primary aldosteronism (PA) is the consequence of a monoclonal or multiclonal process is unclear.

Case description

A 48-year-old man with severe bilateral PA refractory to medical therapy underwent unilateral adrenalectomy of the dominant adrenal. Although computed tomography showed three left-sided cortical nodules, postsurgical histopathology and genetic analysis revealed five different adrenocortical adenomas. Two zona fasciculata (ZF)-like aldosterone-producing adenomas (APAs) each harbored distinct known somatic KCNJ5 mutations (L168R and T158A). A zona glomerulosa-like APA harbored a known CACNA1D G403R somatic mutation, whereas a zona reticularis-like adenoma, which was grossly black in pigmentation with histologic characteristics more associated with c

SUBMITTER: Omata K 

PROVIDER: S-EPMC5470766 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature