Ontology highlight
ABSTRACT:
SUBMITTER: Roth B
PROVIDER: S-EPMC5470961 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Oncotarget 20170501 21
Epithelial-to-mesenchymal transition (EMT) has been implicated in the progression of bladder cancer. To study its contribution to bladder cancer metastasis, we established new xenograft models derived from human bladder cancer cell lines utilizing an orthotopic "recycling" technique that allowed us to isolate and examine the primary tumor and its corresponding circulating tumor cells (CTC's) and metastatic lesions. Using whole genome mRNA expression profiling, we found that a reversible epitheli ...[more]