Gene-gene interaction between PPARG and CYP1A1 gene on coronary artery disease in the Chinese Han Population.

ABSTRACT:

Aims

To observe the influence of the peroxisome proliferator-activator receptor-G (PPAR-G) gene and cytochrome P4501A1 (CYP1A1) single-nucleotide polymorphisms (SNPs), and interactions among several SNPs on coronary artery disease (CAD) risk.

Methods

A total of 1106 participants (including 583 males and 523 females) including 550 CAD patients and 556 control subjects were recruited in this study, and the mean age for these participants was 55.5 ± 11.8 years old. Logistic regression was used to observe association of SNP within PPARG and CYP1A1 with CAD risk and GMDR model was used to screen the best interaction combinations.

Results

CAD susceptibility was higher in those with homozygous mutant of rs10865710, rs1805192 and rs4646903 than those with wild-type homozygote

SUBMITTER: Zhang X 

PROVIDER: S-EPMC5470977 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature