DNA methylation of METTL7A gene body regulates its transcriptional level in thyroid cancer.

ABSTRACT: DNA methylation is the best-studied epigenetic mechanism for regulating gene transcription and maintaining genome stability. Current research progress of transcriptional regulation by DNA methylation mostly focuses on promoter region where hypomethylated CpG islands are present transcriptional activity, as hypermethylated CpG islands generally result in gene repression. Recently, the DNA methylation patterns across the gene body (intragenic methylation) have increasingly attracted attention towards their role in transcriptional regulation and efficiency, due to the improvement of numerous genome-wide DNA methylation profiling studies. However, the function and mechanism of gene body methylation is still unclear. In this study, we revealed that the methylation level of METTL7A, a seldom stu

SUBMITTER: Zhou S 

PROVIDER: S-EPMC5470999 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature