High NUCB2 expression level represents an independent negative prognostic factor in Chinese cohorts of non-metastatic clear cell renal cell carcinoma patients.

ABSTRACT:

Background

This study aimed to investigate the prognostic significance of NUCB2 in clear cell renal cell carcinoma.

Patients and methods

The study retrospectively enrolled a training set (182 patients) and a validation set (434 patients) with non-metastasis (pT1-3N0M0) ccRCC from two institutional medical centers of China. NUCB2 protein expression was evaluated by immunohistochemical staining of NUCB2 antibody, and its association with clinicopathological characteristics and clinical outcomes were evaluated. The NUCB2 mRNA transcription level was evaluated through TCGA KIRC cohort (190 patients). Prognostic accuracies were evaluated by C index and Akaike information criterion.

Results

In ccRCC tissues, NUCB2 protein expression level was positively correlated with Fuhr

SUBMITTER: Fu H 

PROVIDER: S-EPMC5471050 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature