Should surgery be conducted for small nonfunctioning pancreatic neuroendocrine tumors: a systemic review.

ABSTRACT:

Background

The incidence of nonfunctioning pancreatic neuroendocrine tumors smaller than 2cm has increased remarkably in the last two decades. Controversies exist regarding whether surgery should be conducted for this group of tumors.

Methods

MEDLINE, EMBASE and CENTRAL were search until 2017/01/17. Studies with comparative results between operation and observation group were included. Primary outcomes were overall survival and disease specific survival. Secondary outcomes were disease progression and surgical death and complications.

Results

6 studies with a total of 1861 patients were identified. No randomized controlled trials were found. Survival rate was high (97-100%) and no patients died because of the disease in 5 of the 6 studies, with no difference between o

SUBMITTER: Guo J 

PROVIDER: S-EPMC5471061 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature