Sulforaphane for the chemoprevention of bladder cancer: molecular mechanism targeted approach.

ABSTRACT: The clinical course for both early and late stage Bladder Cancer (BC) continues to be characterized by significant patient burden due to numerous occurrences and recurrences requiring frequent surveillance strategies, intravesical drug therapies, and even more aggressive treatments in patients with locally advanced or metastatic disease. For these reasons, BC is also the most expensive cancer to treat. Fortunately, BC offers an excellent platform for chemoprevention interventions with potential to optimize the systemic and local exposure of promising agents to the bladder mucosa. However, other than smoking cessation, there is a paucity of research that systematically examines agents for chemoprevention of bladder cancers. Adopting a systematic, molecular-mechanism based approach, the goal

SUBMITTER: Leone A 

PROVIDER: S-EPMC5471065 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature