Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7.

ABSTRACT: The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis. We investigated the expression mechanism and function of the purinergic receptor P2X7 in contraction of intestinal CD4⁺ effector T cells. We found that P2X7 upregulation on CD4⁺ effector T cells is induced by retinoic acid through retinoic acid receptor α binding to an intragenic enhancer region of the P2rx7 gene. P2X7 is highly expressed by most intestinal αβ and γδ T cells, including T-helper type 1 (Th1) and Th17 cells. The intestinal effector T cells are effectively deleted by P2X7 activation-dependent apoptosis. Moreover, P2X7

SUBMITTER: Hashimoto-Hill S 

PROVIDER: S-EPMC5471139 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature