Dietary Changes Impact the Gut Microbe Composition in Overweight and Obese Men with Prostate Cancer Undergoing Radical Prostatectomy.

ABSTRACT:

Background

Diet and obesity influence prostate cancer risk and progression-effects that may be mediated through the gut microbiome.

Objective

Our aim was to explore relationships among diet, gut microbes, and Gleason sum in overweight and obese prostate cancer patients enrolled in a presurgical weight-loss trial.

Design

Randomized controlled trial (NCT01886677) secondary analysis.

Participants/setting

In 2013-2014, 40 prostate cancer patients in the southeastern United States were randomized and allocated equally to weight-loss and wait-list control arms while they awaited prostatectomy; stool samples were collected on a subset of 22 patients.

Intervention

Registered dietitian nutritionists and exercise physiologists provided semi-weekly in-person and te

SUBMITTER: Fruge AD 

PROVIDER: S-EPMC5471140 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature