Non-muscle myosin II is required for correct fate specification in the Caenorhabditis elegans seam cell divisions.

ABSTRACT: During development, cell division often generates two daughters with different developmental fates. Distinct daughter identities can result from the physical polarity and size asymmetry itself, as well as the subsequent activation of distinct fate programmes in each daughter. Asymmetric divisions are a feature of the C. elegans seam lineage, in which a series of post-embryonic, stem-like asymmetric divisions give rise to an anterior daughter that differentiates and a posterior daughter that continues to divide. Here we have investigated the role of non-muscle myosin II (nmy-2) in these asymmetric divisions. We show that nmy-2 does not appear to be involved in generating physical division asymmetry, but nonetheless is important for specifying differential cell fate. While cell polarity appe

SUBMITTER: Ding SS 

PROVIDER: S-EPMC5471188 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature