Transcriptome analysis reveals similarities between human blood CD3^- CD56^bright cells and mouse CD127⁺ innate lymphoid cells.

ABSTRACT: For many years, human peripheral blood natural killer (NK) cells have been divided into functionally distinct CD3^- CD56^bright CD16^- and CD3^- CD56^dim CD16⁺ subsets. Recently, several groups of innate lymphoid cells (ILC), distinct from NK cells in development and function, have been defined in mouse. A signature of genes present in mouse ILC except NK cells, defined by Immunological Genome Project studies, is significantly over-represented in human CD56^bright cells, by gene set enrichment analysis. Conversely, the signature genes of mouse NK cells are enriched in human CD56^dim cells. Correlations are based upon large differences in expression of a few key genes. CD56^bright cells show preferent

SUBMITTER: Allan DSJ 

PROVIDER: S-EPMC5471261 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature