Reconstruction of pathway modification induced by nicotinamide using multi-omic network analyses in triple negative breast cancer.

ABSTRACT: Triple negative breast cancer (TNBC) is characterized by an aggressive biological behavior in the absence of a specific target agent. Nicotinamide has recently been proven to be a novel therapeutic agent for skin tumors in an ONTRAC trial. We performed combinatory transcriptomic and in-depth proteomic analyses to characterize the network of molecular interactions in TNBC cells treated with nicotinamide. The multi-omic profiles revealed that nicotinamide drives significant functional alterations related to major cellular pathways, including the cell cycle, DNA replication, apoptosis and DNA damage repair. We further elaborated the global interaction networks of molecular events via nicotinamide-inducible expression changes at the mRNA and functional protein levels. This approach indicated t

SUBMITTER: Kim JY 

PROVIDER: S-EPMC5471278 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature