Genetic similarities and differences between discoid and systemic lupus erythematosus patients within the Polish population.

ABSTRACT:

Introduction

Many studies have shown that some SNPs might be a risk factor for systemic lupus erythematosus (SLE), but little is known about potential susceptibility loci of the skin types of the disease. Discoid lupus erythematosus (DLE) is the most common form of the cutaneous lupus erythematosus. Nevertheless, a genetic contribution to DLE is not fully recognized.

Aim

We aimed to analyze three SNPs located in the STAT4 (rs7574865), ITGAM (rs1143679) and TNXB (rs1150754) genes in both DLE and SLE patients from Poland.

Material and methods

SNPs were genotyped using real-time polymerase chain reaction (PCR). Statistical significance of the differences between patient and control groups in both allele and genotype frequencies were calculated using

SUBMITTER: Skonieczna K 

PROVIDER: S-EPMC5471372 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature