Riboflavin as a bioorthogonal photocatalyst for the activation of a Pt^IV prodrug.

ABSTRACT: Encouraging developments demonstrate that few transition metal and organometallic catalysts can operate in a bioorthogonal fashion and promote non-natural chemistry in living systems by minimizing undesired side reactions with cellular components. These catalytic processes have potential for applications in medicinal chemistry and chemical biology. However, the stringent conditions of the cell environment severely limit the number of accessible metal catalysts and exogenous reactions. Herein, we report an unorthodox approach and a new type of bioorthogonal catalytic reaction, in which a metal complex is an unconventional substrate and an exogenous biological molecule acts as a catalyst. In this reaction, riboflavin photocatalytically converts a Pt^IV prodrug into cisplatin within

SUBMITTER: Alonso-de Castro S 

PROVIDER: S-EPMC5471451 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature