Human IL-6R^hiTIGIT^- CD4⁺CD127^lowCD25⁺ T cells display potent in vitro suppressive capacity and a distinct Th17 profile.

ABSTRACT: To date many clinical studies aim to increase the number and/or fitness of CD4⁺CD127^lowCD25⁺ regulatory T cells (Tregs) in vivo to harness their regulatory potential in the context of treating autoimmune disease. Here, we sought to define the phenotype and function of Tregs expressing the highest levels of IL-6 receptor (IL-6R). We have identified a population of CD4⁺CD127^lowCD25⁺ TIGIT^- T cells distinguished by their elevated IL-6R expression that lacked expression of HELIOS, showed higher CTLA-4 expression, and displayed increased suppressive capacity compared to IL-6R^hiTIGIT⁺ Tregs. IL-6R^hiTIGIT^- CD127^lowCD25⁺ T cells contained a majority of cell

SUBMITTER: Ferreira RC 

PROVIDER: S-EPMC5471606 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature