Dynamic functional connectivity in bipolar disorder is associated with executive function and processing speed: A preliminary study.

ABSTRACT:

Objective

Disturbances in functional connectivity have been suggested to contribute to cognitive and emotion processing deficits observed in bipolar disorder (BD). Functional connectivity between medial prefrontal cortex (mPFC) and other brain regions may be particularly abnormal. The goal of the present study was to characterize the temporal dynamics of the default mode network (DMN) connectivity in BD and examine its association with cognition.

Method

In a preliminary study, euthymic BD (n = 15) and healthy comparison (HC, n = 19) participants underwent resting-state functional MRI, using high-resolution sequences adapted from the Human Connectome Project, and completed neuropsychological measures of processing speed and executive function. A seed-based approach was used t

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC5471616 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature